Sex differences in cocaine conditioned place preference in C57BL/6J mice
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چکیده
منابع مشابه
mGluR5 Knockout mice exhibit normal conditioned place-preference to cocaine
Metabotropic glutamate receptor 5 (mGluR5) null mutant (-/-) mice have been reported to totally lack the reinforcing or locomotor stimulating effects of cocaine. We tested mGluR5 -/and +/+ mice for their locomotor and conditioned placepreference response to cocaine. Unlike the previous finding, here we show that compared to mGluR5 +/+ mice, -/mice exhibit no difference in the locomotor response...
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Separate groups of rats underwent an unbiased conditioned place preference (CPP) procedure involving alternate pairings of distinct environments with intravenous (IV) injections of cocaine (.75 mg/kg) or saline immediately or 15 min after injection. A subsequent extinction phase consisted of exposure to both conditioning environments preceded by saline injection (Ext). Finally, an IV priming in...
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The involvement of nitric oxide (NO) in the reinforcing properties of opioids was studied by examining the effect of a NO precursor (L-arginine) and NO synthase inhibitor (L-nitro-amino-methyl-ester, L-NAME) on the conditioned place preference (CPP) induced by morphine. The experiment was performed on male albino Swiss- White mice (25 ± 5 g). L-arginine in doses of 100, 200 and 500 mg/kg (i.p...
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متن کاملD-cycloserine accelerates the extinction of cocaine-induced conditioned place preference in C57bL/c mice.
UNLABELLED Recently, it was shown that D-cycloserine (DCS, a NMDA partial agonist) facilitated extinction of fear as well as cocaine conditioned place preference (CPP) in rats. METHODS The present study examined the effects of DCS (15 mg/kg i.p. and 30 mg/kg i.p.) on extinction and renewal of cocaine-induced CPP in C57bL/c mice. In parallel, we examined the effects of DCS on locomotor activit...
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ژورنال
عنوان ژورنال: NeuroReport
سال: 2014
ISSN: 0959-4965
DOI: 10.1097/wnr.0000000000000053